Description: Toll-like Receptors in Inflammation by Luke A.J. O'Neill, Elizabeth Brint TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology. Back Cover Toll-like receptors (TLRs) are critical mediators of the innate immune response in mammals. This family of receptors recognizes a variety of microbial products or motifs and initiates the host response to infection. Examples include TLR4 which recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, TLR3 which recognizes viral double-stranded RNA, and TLR9 which recognizes CpG DNA motifs, found in both viruses and bacteria. All TLRs possess an intracellular region termed the Toll-IL-1 receptor-Resistance (TIR) domain which is essential for signaling from these receptors. The specificity of signaling from individual TLRs arises from differential utilization of adapter proteins. This specificity results in a tailoring of the host defense response depending on the microbe being sensed. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis, and asthma. There is, therefore, great interest in targeting TLRs therapeutically since a disruption of TLR function will result in a decrease in the production of inflammatory mediators. This volume covers our current understanding of TLRs and their role in inflammation. Given the importance of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology. Table of Contents TLRs as bacterial sensors.- Toll-like receptors and rheumatoid arthritis: is there a connection?.- Toll-like receptor 9 and systemic autoimmune diseases.- Toll-like receptors and airway disease.- Toll-like receptors and vascular disease.- Toll-like receptors and inflammatory bowel disease.- Toll-like receptor signaling in the liver.- Toll-like receptors as key sensors of viral infection.- IRAK-4: A key kinase involved in toll-like receptor signaling and resistance to bacterial infection.- Endogenous regulation of toll-like receptor signalling.- Tuning of inflammatory cytokines and toll-like receptors by TIR8/SIGIRR, a member of the IL-1 receptor family with unique structure and regulation.- Toll-like receptors as pharmacological targets. Long Description A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology. Feature Written by leading scientists in the field Covers the current understanding of TLRs and their role in inflammatory diseases Gives outlook on the development of drugs Details ISBN3764372850 Language English ISBN-10 3764372850 ISBN-13 9783764372859 Media Book Format Hardcover Year 2005 Imprint Birkhauser Verlag AG Place of Publication Basel Country of Publication Switzerland Short Title TOLL-LIKE RECEPTORS IN INFLAMM Series Progress in Inflammation Research DOI 10.1007/b107200;10.1007/3-7643-7441-1 Edited by Elizabeth Brint Author Elizabeth Brint Pages 246 Publisher Birkhauser Verlag AG Edition Description 2005 ed. Edition 2005th Publication Date 2005-12-09 DEWEY 616.0473 Audience Professional & Vocational Illustrations XII, 246 p. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:127080497;
Price: 315.84 AUD
Location: Melbourne
End Time: 2025-01-14T04:36:13.000Z
Shipping Cost: 11.98 AUD
Product Images
Item Specifics
Restocking fee: No
Return shipping will be paid by: Buyer
Returns Accepted: Returns Accepted
Item must be returned within: 30 Days
ISBN-13: 9783764372859
Book Title: Toll-like Receptors in Inflammation
Number of Pages: 246 Pages
Language: English
Publication Name: Toll-Like Receptors in Inflammation
Publisher: Birkhauser Verlag Ag
Publication Year: 2005
Subject: Medicine, Biology
Item Height: 244 mm
Item Weight: 636 g
Type: Textbook
Author: Luke A.J. O'neill, Elizabeth Brint
Item Width: 170 mm
Format: Hardcover
