Protein Modules in Signal Transduction by Anthony J. Pawson (English) Paperback

Description: Protein Modules in Signal Transduction by Anthony J. Pawson Estimated delivery 3-12 business days Format Paperback Condition Brand New Description The external signals that control cellular behavior are chanelled through cell surface receptors, that in turn regulate cytoplasmic signaling pathways. Work over the last ten years has indicated that the activation of these intra- cellular signaling pathways depends on a series of protein-protein and protein-phospholipid interactions mediated by modular polypeptide domains. Through their association with specific peptide motifs, these protein modules define a recognition code through which many aspects of cellular function are controlled. The articles in this book describe the varied features of these domains, and outline the structural, biochemical and genetic evidence that demonstrates their importance in co-ordinating cellular responses to external cues. Publisher Description The behavior of eukaryotic cells, particularly those of multicel- lular organisms, depends on the transmission of signals from one cell to another. Such extracellular signals can take the form of hormones, antigens, cells surface molecules, or components of the extracellular matrix and exert their effects by binding to specific receptors, usually exposed on the surface of the target cell. These transmembrane receptors possess a cytoplasmic domain that al- lows communication with intracellular signaling pathways, pro- viding access to the regulation of gene expression, cytoskeletal architecture, cell metabolism, survival, and the cell cycle. Defining the process through which a signal emanating from an individual receptor can influence so many aspects of cellular function is of central importance for our understanding of signal transduction. Many polypeptide factors that regulate cellular growth and differentiation bind to receptors with cytoplasmic tyrosine kinase domains.Recent evidence has indicated that intracellular sig- naling from receptor tyrosine kinases proceeds through a series of modular protein-protein interactions, typified by the interaction of autophosphorylated growth factor receptors with the Src ho- mology 2 (SH2) domains of cytoplasmic target proteins. Thus, a crucial role of tyrosine phosphorylation is to promote the for- mation of protein complexes through the creation of specific SH2 domain-binding sites, thereby regulating the activation of bio- chemical pathways within the cell. Details ISBN 3642804837 ISBN-13 9783642804830 Title Protein Modules in Signal Transduction Author Anthony J. Pawson Format Paperback Year 2011 Pages 368 Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG GE_Item_ID:151482850; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. Returns must be postmarked within 4 business days of authorisation and must be in resellable condition. Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit. For purchases where a shipping charge was paid, there will be no refund of the original shipping charge. Additional Questions If you have any questions please feel free to Contact Us. Categories Baby Books Electronics Fashion Games Health & Beauty Home, Garden & Pets Movies Music Sports & Outdoors Toys

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