Description: Patient-Specific Modeling of the Cardiovascular System Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Technology-Driven Personalized Medicine Author(s): Roy C.P. Kerckhoffs Format: Paperback Publisher: Springer-Verlag New York Inc., United States Imprint: Springer-Verlag New York Inc. ISBN-13: 9781489982421, 978-1489982421 Synopsis Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.
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Book Title: Patient-Specific Modeling of the Cardiovascular System
Number of Pages: 240 Pages
Language: English
Publication Name: Patient-Specific Modeling of the Cardiovascular System: Technology-Driven Personalized Medicine
Publisher: Springer-Verlag New York Inc.
Publication Year: 2014
Subject: Medicine, Engineering & Technology, Biology
Item Height: 235 mm
Item Weight: 409 g
Type: Textbook
Author: Roy C.P. Kerckhoffs
Item Width: 155 mm
Format: Paperback
