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Molecular Diagnostics: Techniques and Applications for the Clinical Laboratory

Description: Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. This handbook provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting. I. Introduction and Methodology   Quantivative PCR: an introduction Signal Amplification Methods in Molecular Diagnostics The Lab-on-a-Chip Approach for Molecular Diagnostics Nucleic Extraction and Amplification General Procedures      II. Quality Assurance, Regulatory, and Ethical Issues   Billing and Reimbursement for Molecular Diagnostics Molecular Pathology and Infectious Diseases Ethical Considerations in Molecular Diagnostics Quality Control, Assurance, Identification and Standards    III. Genetic Disease   Molecular Testing for Cystic Fibrosis and CFTR-Related Conditions Carrier Testing for Neurogenetic Diseases Hemochromatosis Standards and Recommendations for Molecular Diagnostic Testing for Huntington Disease, the Autosomal Dominant Spinocerebellar Ataxias, and Friedreich Ataxia    IV. Cancer   The Role of Micro-RNAs in Cancer Molecular Diagnostics in the Evaluation of Cancer: Modern Concepts and Overview Gene Expression Analysis for Tumor Profiling GEA for TP Molecular Diagnostics of Hematopoetic Malignancies    V. Infectious Diseases    Viruses Hepatic B and C Viruses Molecular Diagnosis of Cytomegalovirus Molecular Detection of Multiple Respiratory Viruses Bacteria Molecular Methods for Identification and Characterization of Acinetobacter species Molecular Detection and Surveillance of Healthcare-Associated Infections Molecular Detection Of Group B Streptococcus Role of Molecular Techniques in the Epidemiologic Investigation Of Hospital-Acquired Infections Human Papilloma Virus and its Role in Cervical Carcinoma    VI. Specialized Applications of Molecular Testing   Molecular HLA Typing Methods Used in Clinical Laboratories Identification through DNA analysis in criminal and family relatedness investigations. VII. Pharmacogenetics   Overview of Pharmacogenomics and Applications for the Modern Clinical Laboratory UDP-Glucuronosyltransferase 1A1 and the Glucuronidation in Oncology Applications and Hyperbilirubinemia Pharmacogenetics of P-450 Enzymes Pharmacogenomics of Thiopurine Methyl Transferase (TPMT): Importance in Monitoring of Mercaptopurine/Azathioprine Therapy

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Molecular Diagnostics: Techniques and Applications for the Clinical LaboratoryMolecular Diagnostics: Techniques and Applications for the Clinical Laboratory

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EAN: 9780123694287

UPC: 9780123694287

ISBN: 9780123694287

MPN: N/A

Item Height: 3.1 cm

Item Length: 27.7 cm

Item Width: 21.8 cm

Publisher: Elsevier Science Publishing Co Inc

Subject: Chemistry

Publication Year: 2009

Number of Pages: 736 Pages

Publication Name: Molecular Diagnostics: Techniques and Applications for the Clinical Laboratory

Language: English

Type: Textbook

Item Weight: 1640 g

Author: Robert M. Nakamura, Charles Strom, Frederick L. Kiechle, Wayne W. Grody

Format: Hardcover

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