Methods of Cancer Diagnosis, Therapy and Prognosis: Colorectal Cancer by M.A. Ha

Description: Methods of Cancer Diagnosis, Therapy and Prognosis by M.A. Hayat This fourth volume in a series devoted to cancer treatment discusses various methodologies for the diagnosis, therapy and prognosis of colorectal cancer. It covers the latest information including standard and emerging therapies and technological advances. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Authors and Co-Authors of Volume 4 Preface Contents of Volume 1, 2, and 3 PART I. COLORECTAL CANCER 1. INTRODUCTION: COLORECTAL CANCER M.A. Hayat INTRODUCTION Screening for Colorectal Cancer Treatment Rectal Cancer REFERENCES A. Diagnosis 2. POORLY DIFFERENTIATED COLORECTAL ADENOCARCINOMA: (METHODOLOGY) Seiichi Shinji, Zenya Naito, Toshiyuki Ishiwata, Yoko Matsuda, Tomoko Seya, and Takashi Tajiri INTRODUCTION HISTOPATHOLOGY IMMUNOHISTOCHEMISTRY FOR DIFFERENTIAL DIAGNOSIS IMMUNOHISTOCHEMISTRY FOR MALIGNANT CHARACATERISTICS OF POORLY DIFFERENTIATED ADENOCARCINOMA IN SITU HYBRIDIZATION FOR MALIGNANT CHARACTERISTICS OF POORLY DIFFERENTIATED ADENOCARCINOMA THERAPY REFERENCES 3. COLORECTAL CANCER: IMMUNOHISTOCHEMICAL; DIAGNOSIS WITH HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K Ayham Alnabulsi, Brian Carpenter, Colin Telfer, and Graeme I. Murray INTRODUCTION BIOMARKERS Approved Biomarkers - Problems Biomarkers of Colorectal Cancer Demand for Colorectal Biomarkers COLORECTAL BIOMARKER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K Methodology 2D Gel Electrophoresis (2DGE) Semiquantitative Reverse Transcription-Polymerase Chain Reaction Monoclonal Antibody to Heterogeneous Nuclear Ribonucleoprotein K Immunohistochemistry (IHC) RESULTS DISCUSSION FUTURE DIRECTION REFERENCES 4. METASTASES AND RECURRENCE OF COLORECTAL CANCER: DIAGNOSTIC ROLE OF IMMUNOSCINTIGRAPHY Vladimir Obradovic and Vera Artiko INTRODUCTION GENERAL CONSIDERATIONS Radiopharmaceuticals Imaging Systems and Techniques IMMUNOSCINTIGRAPHIC METHODS USED FOR DIAGNOSTICS OF COLORECTAL CANCER Immunoscintigraphy Based onRadiopharmaceuticals Labeled with Radioiodines Immunoscintigraphy Based on Radiopharmaceuticals Labeled with 111In Immunoscintigraphy Based on Radiopharmaceuticals Labeled with 99mTc Comparison of Diagnostic Values of Different Radiopharmaceuticals Immunoscintigraphy and Positron Emission Tomography Radioimmunoguided Surgery CONCLUSION REFERENCES 5. COLORECTAL CANCER DIAGNOSIS USING DNA LEVELS IN BLOOD AND STOOL Emanuela Flamini, Daniele Calistri, Laura Mercatali, Claudia Rengucci and Dino Amadori INTRODUCTION AVAILABLE TESTS AND THEIR COST BENEFITS Fecal Occult Blood Test Flexible Sigmoidoscopy Colonoscopy Barium Enema with Air Contrast Virtual Colonoscopy MOLECULAR MARKERS AND THEIR COST BENEFITS FREE CIRCULATING DNA IN BLOOD Biological Mechanisms of Free Circulating DNA Release Methodological Aspects of Free Circulating DNA Sources and Influence of Pre-Analytical Factors Isolation and Quantification Free Circulating DNA Levels in Colorectal Cancer Diagnosis INTEGRITY OF GENOMIC EXTRACTED DNA FROM STOOL Analysis of Long Fragment DNA in Stool Advantages and Technical Problems CONCLUSIONS REFERENCES 6. COLORECTAL CARCINOMA: IDENTIFICATION OF microRNAs USING REAL-TIME POLYMERASE CHAIN REACTION Eva Bandres, Nerea Bitarte, Natalia Ramirez, Ruth Zarate, and Jesus Garcia-Foncillas INTRODUCTION GENOMICS OF microRNA microRNA BIOGENESIS AND FUNCTION EVIDENCE FOR THE INVOLVEMENT OF microRNA IN CANCER REGULATION OF microRNA EXPRESSION IDENTIFICATION OF microRNA TARGETS: BIOINFORMATIC AND FUNCTIONAL TOOLS TECHNOLOGY TO QUANTIFY microRNAs EXPERIMENTAL WORKFLOW FOR microRNA EXPRESSION BY REAL- TIME POLYMERASE CHAIN REACTION IDENTIFICATION OF DIFFERENTIALLY EXPRESSED microRNA IN COLORECTAL CANCER USING REAL-TIME POLYMERASE CHAIN REACTION Q Back Cover This fourth volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis discusses various methodologies for the diagnosis, therapy and prognosis of Colorectal Cancer. Both standard and emerging therapies for this cancer, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume: * Presents surgical, radiological, and molecular therapies and prognostic markers for colorectal cancer. * Highlights a large number of methods for diagnosing colorectal cancer at various stages of development, including immunohistochemistry, in situ hybridization immunoscintigraphy, RT- PCR, free circulating DNA levels in blood and stool, ultrasonography, CT, PET, and MRI. * Includes imaging technologies for assessing treatment results, and details related to colonoscopy and sigmoidoscopy. * Explains the use of anticancer agents and monoclonal antibodies, including 5-fluorouracil, fluoropyrimidines, leucovorin, irinotecan, oxaliplatin, raltitrexed, capecitabine, cetuximab, and bevacizumab. * Compares preoperative chemoradiotherapy with postoperative chemoradiotherpy. The technological advances presented in this volume are expected to expedite new discoveries and their translation to clinical practice. The field of oncology will benefit the most from these advanced methods, as a combination of therapies and personalized medicine will improve early detection of colorectal cancer and other cancer types. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology. Table of Contents Colorectal Cancer.- Introduction: Colorectal Cancer.- Poorly Differentiated Colorectal Adenocarcinoma (Methodology).- Colorectal Cancer: Immunohistochemical Diagnosis with Heterogeneous Nuclear Ribonucleoprotein K.- Metastases and Recurrence of Colorectal Cancer: Diagnostic Role of Immunoscintigraphy.- Colorectal Cancer Diagnosis Using DNA Levels in Blood and Stool.- Colorectal Carcinoma: Identification of MicroRNAs Using Real-Time Polymerase Chain Reaction.- Colorectal Cancer: Optimization of the Combination of 5-Fluorouracil and Irinotecan.- Detection of Abdominal Abscesses After Colorectal Surgery: Ultrasonography, Computed Tomography and Gallium Scan.- Antimetastatic Therapy in Colorectal Cancer: Role of Tumor Cell Matrix Metalloproteinase 9 (Methodology).- Endoscopic Resection of Early Colorectal Tumors: Novel Diagnostic and Therapeutic Techniques.- Role of Stromal Variables in Development and Progression of Colorectal Cancer.- Quantitative Assessment of Colorectal Cancer Perfusion: Perfusion Computed Tomography and Dynamic Contrast Enhanced Magnetic Resonance Imaging.- Positron Emission Tomography and Colorectal Cancer.- Prognostic Significance of Protein Markers in Colorectal Cancer Stratified by Mismatch Repair Status.- Colorectal Cancer: Lactate Dehydrogenase (LDH) Activity as a Prognostic Marker.- Colon Cancer.- Detection of Tumor Cells in Lymph Nodes of Colon Cancer Patients Using Real-Time Quantitative Reverse Transcription-Polymerase Chain Reaction.- Colon Cancer: Laparoscopic Surgery.- Sentinel Node-Based Immunotherapy of Colon Cancer.- Rectal Cancer.- Rectal Cancer: Preoperative Staging Using Endorectal Ultrasonography (Methodology).- Rectal Cancer: Spectral Imaging and Immunohistochemistry of Thymidylate Synthase.- Cancer of the Rectum: Abdominoperinealand Sphincter-Saving Resections.- Chemoradiation for Rectal Cancer.- Resectable Rectal Cancer: Preoperative Short-Course Radiation.- Preoperative Chemoradiotherapy Allows for Local Control in Rectal Cancer – But Distant Metastases Remain an Unsolved Problem.- Locally Advanced Rectal Cancer: Combined Chemotherapy During Preoperative Radiation Therapy.- Colorectal Liver Metastases.- Colorectal Cancer Liver Metastases: Neoadjuvant Therapy with Bevacizumab.- Colorectal Liver Metastases: Radiofrequency Ablation.- Anal Cancer.- Anal Squamous Cell Carcinomas: Diagnosis Using p63 Immunohistochemistry.- Molecular and Clinicopathologic Features Which Predict Outcome in Patients with Anorectal Melanoma. Feature The only book that discusses cancer diagnosis, therapy, and prognosis together in one volume Discusses the molecular processes that lead to the development and proliferation of cancer cells Includes recent major advances in cancer diagnosis and therapy assessment The text is supported throughout with illustrations The information in the book identifies patients with high likelihood of clinical benefits from a specific treatment Details ISBN9401777292 Pages 503 Publisher Springer Series Methods of Cancer Diagnosis, Therapy and Prognosis Year 2016 ISBN-10 9401777292 ISBN-13 9789401777292 Format Paperback Publication Date 2016-08-23 Imprint Springer Subtitle Colorectal Cancer Place of Publication Dordrecht Country of Publication Netherlands Edited by M. A. Hayat DEWEY 616.994347 Short Title Methods of Cancer Diagnosis, Therapy and Prognosis Language English Series Number 4 UK Release Date 2016-08-23 Illustrations XXXVIII, 503 p. Author M.A. Hayat Birth 1970 Affiliation Universite Sorbonne Nouvelle Paris 3 Position Royalty Account Edition Description Softcover reprint of the original 1st ed. 2009 Alternative 9781402095443 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:131041358;

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