Description: Matrix Metalloproteinase Inhibitors by Satya Prakash Gupta Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development. Notes Focus on quantitative structure-activity relationship of MMP inhibitorsContains an overview of endogenous tissue inhibitors of MMPs and their biological relevanceWritten by experts in the field Back Cover Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development. Table of Contents Matrix Metalloproteinases.- Specificity of Binding with Matrix Metalloproteinases.- The Gelatinases and Their Inhibitors: The Structure–Activity Relationships.- Advances in Studies on Collagenase Inhibitors.- Hydroxamic Acids as Matrix Metalloproteinase Inhibitors.- Quantitative Structure–Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors.- Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease. Feature Focus on quantitative structure-activity relationship of MMP inhibitors Contains an overview of endogenous tissue inhibitors of MMPs and their biological relevance Written by experts in the field Details ISBN303480363X Short Title MATRIX METALLOPROTEINASE INHIB Series Experientia Supplementum Language English ISBN-10 303480363X ISBN-13 9783034803632 Media Book Format Hardcover Series Number 103 Subtitle Specificity of Binding and Structure-Activity Relationships Year 2012 Imprint Springer Basel Country of Publication Switzerland Edited by Satya Prakash Gupta Pages 286 Edition 2012th Illustrations X, 286 p. DOI 10.1007/978-3-0348-0364-9 Publication Date 2012-04-07 Author Satya Prakash Gupta Publisher Springer Basel Edition Description 2012 ed. Alternative 9783034807647 DEWEY 612.8 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96312211;
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ISBN-13: 9783034803632
Book Title: Matrix Metalloproteinase Inhibitors
Number of Pages: 286 Pages
Language: English
Publication Name: Matrix Metalloproteinase Inhibitors: Specificity of Binding and Structure-Activity Relationships
Publisher: Springer Basel
Publication Year: 2012
Subject: Biology
Item Height: 235 mm
Item Weight: 612 g
Type: Textbook
Author: Satya Prakash Gupta
Item Width: 155 mm
Format: Hardcover
