In Silico Models for Drug Discovery by Sandhya Kortagere (English) Paperback Boo

Description: In Silico Models for Drug Discovery by Sandhya Kortagere Written by leading experts in the field, chapters cover topics such as techniques to derive novel antimicrobial targets, methods of interpreting polypharmacology-based drug target networks, and molecular dynamics techniques used to compute binding energies of drugs to their target proteins, to name a few. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Infectious diseases caused by viruses, parasites, bacteria, and fungi are the number one cause of death worldwide. Although new technologies have improved diagnosis of infectious diseases, the efficacy of all known current anti-infective agents is threatened by the spread of drug-resistant forms of the pathogens. Hence, there remains an urgent need to develop anti-infective agents that target drug-resistant pathogens. In Silico Models for Drug Discovery presents a comprehensive look at the role in silico models play in understanding infectious diseases and in developing novel therapeutics to treat them. Written by leading experts in the field, chapters cover topics such as techniques to derive novel antimicrobial targets, methods of interpreting polypharmacology-based drug target networks, and molecular dynamics techniques used to compute binding energies of drugs to their target proteins, to name a few. Written in the successful Methods in Molecular Biology™ series or in review article format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Silico Models for Drug Discovery seeks to serve both professionals and novices involved in the study and treatment of infectious diseases. Back Cover Infectious diseases caused by viruses, parasites, bacteria, and fungi are the number one cause of death worldwide. Although new technologies have improved diagnosis of infectious diseases, the efficacy of all known current anti-infective agents is threatened by the spread of drug-resistant forms of the pathogens. Hence, there remains an urgent need to develop anti-infective agents that target drug-resistant pathogens. In Silico Models for Drug Discovery presents a comprehensive look at the role in silico models play in understanding infectious diseases and in developing novel therapeutics to treat them. Written by leading experts in the field, chapters cover topics such as techniques to derive novel antimicrobial targets, methods of interpreting polypharmacology-based drug target networks, and molecular dynamics techniques used to compute binding energies of drugs to their target proteins, to name a few. Written in the successful Methods in Molecular Biology(tm) series or in review article format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Silico Models for Drug Discovery seeks to serve both professionals and novices involved in the study and treatment of infectious diseases. Table of Contents Virtual Screening in Drug Design.- In Silico Systems Biology Approaches for the Identification of Antimicrobial Targets.- Genome Comparisons as a Tool for Antimicrobial Target Discovery.- In Silico Models for Drug Resistance.- An In Silico Model for Interpreting Polypharmacological Relationships in Drug-Target Networks.- On Exploring Structure–Activity Relationships.- Molecular Dynamics Simulations in Drug Design.- Databases and In Silico Tools for Vaccine Design.- In Silico Models for B-Cell Epitope Recognition and Signaling.- The Collaborative Drug Discovery (CDD) Database.- Recognition of Nontrivial Remote Homology Relationships Involving Proteins of Helicobacter pylori: Implications for Function Recognition.- Identification of Novel Anthrax Toxin Countermeasures Using In Silico Methods.- Rational Design of HIV-1 Entry Inhibitors.- Malarial Kinases: Novel Targets for In Silico Approaches to Drug Discovery.- Designing Novel Inhibitors of Trypanosoma brucei.- Computational Models for Tuberculosis Drug Discovery. Feature Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts Details ISBN1493962973 Pages 265 Publisher Humana Press Inc. Series Methods in Molecular Biology Year 2016 ISBN-10 1493962973 ISBN-13 9781493962976 Format Paperback Publication Date 2016-08-23 Imprint Humana Press Inc. Place of Publication Totowa, NJ Country of Publication United States Edited by Sandhya Kortagere DEWEY 615 Language English Series Number 993 UK Release Date 2016-08-23 AU Release Date 2016-08-23 NZ Release Date 2016-08-23 US Release Date 2016-08-23 Author Sandhya Kortagere Birth 1959 Affiliation UCLA School of Law Position Professor in the Foreign Language Institute Qualifications J.D. Edition Description Softcover reprint of the original 1st ed. 2013 Alternative 9781627033411 Audience Professional & Vocational Illustrations XII, 265 p. 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