DNA Methylation and Cancer Therapy by Moshe Szyf (English) Paperback Book

Description: DNA Methylation and Cancer Therapy by Moshe Szyf Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description This book provides a comprehensive analysis of implications of DNA methylation on cancer diagnosis and cancer therapy. This unique volume focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Key features of this book include discussions of the following topics: The molecular machinery responsible for DNA methylation and their impact on gene expression and tumorigenesis. The emerging relation between DNA methylation and chromatin modifying proteins. How the relationship between DNA methylation and chromatin modifying proteins might clarify the mechanisms and therapeutic implications of aberrant DNA methylation in cancer. Illustrations of the diagnostic potential of methylation in cancer and novel tools for using methylation profiling of cancers. The therapeutic potential of the DNA methylation machinery and novel attempts to target the DNA methylation enzymes in anticancer therapy.This book will be of interest to a wide audience, including oncologists, researchers and clinicians, and graduate students in the fields of oncology, molecular biology, and cancer therapy, as well as researchers and decision-makers in industry focusing on anticancer drugs and diagnosis. Notes DNA Methylation and Cancer Theraphy focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Table of Contents DNA Methylation.- Epigenetic Mechanisms of Gene Regulation.- DNA Hypo- vs. Hypermethylation in Cancer.- DNA Methylation in Urological Cancers.- DNA Methylation in Colorectal Cancer.- CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer.- The Loss of Methyl Groups in DNA of Tumor Cells and Tissues.- Identifying Clinicopathological Association of DNA Hypermethylation in Cancers Using CpG Island Microarrays.- Methylation Analysis in Cancer.- Regulation of DNA Methyltransferases in Cancer.- Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation.- The Role of Active Demethylation in Cancer and Its Therapeutic Potential.- Purine Analogues and Their Role in Methylation and Cancer Chemotherapy.- DNA Methyltransferase Inhibitors.- Preclinical and Clinical Studies on 5-Aza-2?-Deoxycytidine, a Potent Inhibitor of DNA Methylation, in Cancer Therapy.- Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense.- Epilogue. Long Description NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Feature DNA Methylation and Cancer Theraphy focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Details ISBN1441934162 Author Moshe Szyf Series Medical Intelligence Unit Year 2010 ISBN-10 1441934162 ISBN-13 9781441934161 Format Paperback Imprint Springer-Verlag New York Inc. Place of Publication New York, NY Country of Publication United States DEWEY 616.99406 Edition 1st Short Title DNA METHYLATION & CANCER THERA Language English Media Book Illustrations 2 Illustrations, color; 67 Illustrations, black and white; XV, 239 p. 69 illus., 2 illus. in color. Pages 239 AU Release Date 2010-12-06 NZ Release Date 2010-12-06 US Release Date 2010-12-06 UK Release Date 2010-12-06 Publisher Springer-Verlag New York Inc. Edition Description Softcover reprint of hardcover 1st ed. 2005 Publication Date 2010-12-06 Alternative 9780306478482 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96239126;

Price: 411.51 AUD

Location: Melbourne

End Time: 2025-02-06T09:06:31.000Z

Shipping Cost: 9.46 AUD