Centromere: Structure and Evolution by Durdica Ugarkovic (English) Hardcover Boo

Description: Centromere by Durdica Ugarkovic Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA–protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements. Despite this conserved function, centromeres exhibit dramatic difference in structure, size, and complexity. Extensive studies on centromeric DNA revealed its rapid evolution resulting often in significant difference even among closely related species. Such a plasticity of centromeric DNA could be explained by epigenetic c- trol of centromere function, which does not depend absolutely on primary DNA sequence. According to epigenetic centromere concept, which is thoroughly d- cussed by Tanya Panchenko and Ben Black in Chap. 1 of this book, centromere activation or inactivation might be caused by modifications of chromatin. Such acquired chromatin epigenetic modifications are then inherited from one cell di- sion to the next. Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin. Recent insights into the CenH3 presented in this chapter add important mechanistic understanding of how centromere identity is initially established and subsequently maintained in every cell cycle. Notes Unique overview on the centromere research of the last decadeSpecial focus on centromere evolution Back Cover The centromere is a chromosomal locus that regulates the proper pairing and segregation of the chromosomes during cell division. Despite their conserved, essential function, centromeres are characterized by the rapid evolution of both centromeric DNA and proteins. This book presents current views on centromere structure and identity. It deals with the epigenetic concept of centromere establishment and maintenance as well as with the role of DNA and centromeric transcripts in centromere formation and function. Special emphasis is placed on centromere evolution: different evolutionary models are discussed in detail and the latest research on the evolution of new centromeres and neocentromeres is presented. Table of Contents The Epigenetic Basis for Centromere Identity.- The Centromere-Drive Hypothesis: A Simple Basis for Centromere Complexity.- Centromere-Competent DNA: Structure and Evolution.- The Role of ncRNA in Centromeres: A Lesson from Marsupials.- Evolutionary New Centromeres in Primates.- Structure and Evolution of Plant Centromeres. Long Description The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA-protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements. Despite this conserved function, centromeres exhibit dramatic difference in structure, size, and complexity. Extensive studies on centromeric DNA revealed its rapid evolution resulting often in significant difference even among closely related species. Such a plasticity of centromeric DNA could be explained by epigenetic c- trol of centromere function, which does not depend absolutely on primary DNA sequence. According to epigenetic centromere concept, which is thoroughly d- cussed by Tanya Panchenko and Ben Black in Chap. 1 of this book, centromere activation or inactivation might be caused by modifications of chromatin. Such acquired chromatin epigenetic modifications are then inherited from one cell di- sion to the next. Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin. Recent insights into the CenH3 presented in this chapter add important mechanistic understanding of how centromere identity is initially established and subsequently maintained in every cell cycle. Feature Unique overview on the centromere research of the last decade Special focus on centromere evolution Details ISBN3642001815 Short Title CENTROMERE Series Progress in Molecular and Subcellular Biology Language English ISBN-10 3642001815 ISBN-13 9783642001819 Media Book Format Hardcover Series Number 48 Year 2009 Narrator Durdica Ugarkovic Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Subtitle Structure and Evolution Place of Publication Berlin Country of Publication Germany DEWEY 571.844 Edited by Durdica Ugarkovic Edition 2009th Author Durdica Ugarkovic DOI 10.1007/978-3-642-00182-6 Pages 184 Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Edition Description 2009 ed. Publication Date 2009-05-29 Alternative 9783642101236 Audience Professional & Vocational Illustrations 15 Illustrations, color; 20 Illustrations, black and white; X, 184 p. 35 illus., 15 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96309680;

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