Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis

Description: This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results. Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment. Part I: Background: Epigenetic Mechanism 1. Cancer Epigenetics: An Introduction Rajnee Kanwal, Karishma Gupta, and Sanjay Gupta 2. Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program John S. Satterlee, Andrea Beckel-Mitchener, Kim McAllister, Dena C. Procaccini, Joni L. Rutter, Frederick L. Tyson, and Lisa Helbling Chadwick 3. Epigenome-Wide Association Studies (EWAS): Past, Present, and Future James M. Flanagan 4. Epigenetic Biomarkers in Liver Cancer Krishna K. Banaudha and Mukesh Verma Part II: Cancer Specific Type Epigenetic Changes 5. Cancer Type Specific Epigenetic Changes: Gastric Cancer Danielle Queiroz Calcagno, Marília de Arruda Cardoso Smith, and Rommel Rodriguez Burbano 6. Beyond the Island: Epigenetic Biomarkers of Colorectal and Prostate Cancer Andrea J. Savio and Bharati Bapat 7. Prostate Cancer Epigenome Swathi Chinaranagari, Pankaj Sharma, Nathan J. Bowen, and Jaideep Chaudhary 8. CpG Island Hypermethylation as a Biomarker for the Early Detection of Lung Cancer Yujin Kim and Duk-Hwan Kim 9. Analysis of DNA Methylation in Pancreatic Cancer: An Update Christian Pilarsky and Robert Grützmann 10. Epigenetics of Urothelial Carcinoma Wolfgang A. Schulz, Evangelia A. Koutsogiannouli, Günter Niegisch, and Michèle J. Hoffmann 11. Epigenetics of Prostate Cancer Tawnya C. McKee and James V. Tricoli 12. Methylation Profile Landscape in Mesothelioma: Possible Implications in Early Detection, Disease Progression, and Therapeutic Options Xinbo Zhang, Naimei Tang, Arun K. Rishi, Harvey I. Pass, and Anil Wali Part III: Methods and Technologies Used for Detecting Epigenetic Changes 13. Techniques to Access Histone Modifications and Variants in Cancer Monica Tyagi, Shafqat A Khan, Saikat Bhattacharya, Divya Reddy, Ajit K Sharma, Bharat Khade, and Sanjay Gupta 14. Single Base Resolution Analysis of 5-Methylcytosine and 5-Hydroxymethylcytosine by RRBS and TAB-RRBS Maria A. Hahn, Arthur X. Li, Xiwei Wu, and Gerd P. Pfeifer 15. Quantitative DNA Methylation Analysis for Epigenotyping of Colorectal Cancer Atsushi Kaneda and Koichi Yagi 16. Histone Modifications Associated with Cancer Cell Migration and Invasion Miki Hieda, Nariaki Matsuura, and Hiroshi Kimura Part IV: Factors that Influence Epigenetic Changes in Cancer 17. Aberrant Epigenetic Modifications in Radiation-Resistant Head and Neck Cancers Hon-Yi Lin, Tim Hui-Ming Huang, and Michael Wing-Yan Chan 18. Cancer-Associated Infectious Agents and Epigenetic Regulation Vidya Vedham and Mukesh Verma 19. Toxicoepigenomics and Cancer: Implications for Screening Mukesh Verma 20. Human Papilloma Virus (HPV) Modulation of the HNSCC Epigenome Josena K. Stephen and Maria J. Worsham 21. Epigenetic Regulation of HIV, AIDS, and AIDS-Related Malignancies Mukesh Verma 22. Epigenetics of Colorectal Cancer Wenji Yan and Mingzhou Guo 23. Epigenetics in Breast and Prostate Cancer Yanyuan Wu, Marianna Sarkissyan, and Jaydutt V. Vadgama Part V: Future Directions: Risk Assessment, Diagnosis, Treatment, and Prognosis 24. Epigenetic Inhibitors Mukesh Verma and Hirendra Nath Banerjee 25. Use of Epigenetic Modulators as a Powerful Adjuvant for Breast Cancer Therapies Aurore Claude-Taupin, Michael Boyer-Guittaut, Régis Delage-Mourroux, and Eric Hervouet 26. Epigenetic Approaches in Glioblastoma Multiforme and Their Implication in Screening and Diagnosis Gwyneth Hyman, Vinod Manglik, Jeffrey M. Rousch, Mukesh Verma, David Kinkebiel, and Hirendra Nath Banerjee 27. Detection of Circulatory MicroRNAs in Prostate Cancer Anvesha Srivastava, Helle Goldberger, Zainab Afzal, Simeng Suy, Sean P. Collins, and Deepak Kumar 28. Identification and Characterization of Small-Molecule Inhibitors of Lysine Acetyltransferases Daiqing Liao 29. Epigenetic Regulation in Biopsychosocial Pathways Kristin Litzelman and Mukesh Verma 30. Viral Epigenetics Barry I. Milavetz and Lata Balakrishnan 31. P53 Tumor Suppression Network in Cancer Epigenetics Alok Mishra, Daniel J. Brat, and Mukesh Verma 32. Promoter Hypermethylation as a Biomarker in Prostate Adenocarcinoma Jong Y. Park 33. Sequencing the Cancer Methylome Austin Y. Shull, Satish K. Noonepalle, Eun-Joon Lee, Justin Choi, and Huidong Shi 34. Global DNA Methylation Profiling Technologies and the Ovarian Cancer Methylome Jessica Tang, Fang Fang, Dave F. Miller, Jay M. Pilrose, Daniela Matei, Tim H.-M. Huang, and Kenneth P. Nephew 35. Recent Progress in the Discovery of Epigenetic Inhibitors for the Treatment of Cancer Sharad K. Verma 36. At the Crossroad Between Obesity and Gastric Cancer Robert B. Uddo, Jone Garai, Maura C. Mohler, Nicole Pelligrino, Richard Scribner, Melinda S. Sothern, and Jovanny Zabaleta 37. Detection of Epigenetic Aberrations in the Development of Hepatocellular Carcinoma Yujing Zhang 38. Specific Type Epigenetic Changes in Cervical Cancers Shuping Zhao 39. Epigenetics in Head and Neck Cancer Syeda Marriam Bakhtiar, Amjad Ali, and Debmalya Barh 40. Epigenetic Therapy for Colorectal Cancer Vivek Vaish, Tripti Khare, Mukesh Verma, and Sharad Khare

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