Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy

Description: Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy by Matthias J.N.JUNK In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the proteins adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the materials hosting properties and enable unforeseen complex catalytic functionalities. Notes Nominated by Max-Planck-Institute for Polymer Research, Mainz, GermanyInnovative approach to assess the topicDelivers remarkable new insights into materials Back Cover In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure - a consequence of the proteins adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the materials hosting properties and enable unforeseen complex catalytic functionalities. Table of Contents Electron Paramagnetic Resonance Theory.- The Functional Structure of Human Serum Albumin.- Copper Complexes of Star-Shaped Cholic Acid Oligomers with 1,2,3-Triazole Moieties.- Nano-Inhomogeneities in Structure and Reactivity of Thermoresponsive Hydrogels.- Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents.- Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers. Feature Nominated by Max-Planck-Institute for Polymer Research, Mainz, Germany Innovative approach to assess the topic Delivers remarkable new insights into materials Details ISBN364225134X Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Series Springer Theses ISBN-10 364225134X ISBN-13 9783642251344 Format Hardcover Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany DEWEY 541.22 Short Title ASSESSING THE FUNCTIONAL STRUC Language English Media Book Pages 212 Edition 2012th Illustrations XVI, 212 p. DOI 10.1007/978-3-642-25135-1 Year 2012 Publication Date 2012-01-05 Author Matthias J.N.JUNK Edition Description 2012 ed. Alternative 9783642437953 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96310299;

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