Applications of Toxicogenomics in Safety Evaluation and Risk Assessment by Darre

Description: Applications of Toxicogenomics in Safety Evaluation and Risk Assessment by Darrell R. Boverhof, B. Bhaskar Gollapudi This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. With the stress on practical risk assessment, the book sets a foundation for moving toxicogenomics from just a hot technology to an accepted approach. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm. Back Cover Risk assessment and toxicogenomics -- a practical review The past decade has seen growing interest in the use of toxicogenomics for hazard evaluation and chemical safety assessment. This book addresses the need in the field for a comprehensive, up-to-date review of this emerging technology, providing toxicologists and regulatory scientists with practical considerations to take advantage of toxicogenomics when conducting risk assessment of industrial chemicals, pharmaceuticals, agrochemicals, and consumer products. Written by leading scientists experienced in the application of toxicogenomics data, this book includes a complete introduction to toxicogenomics and the principles of risk assessment, examines the potential of the technology to improve risk assessment practices, and offers insight into promising future trends. The emphasis throughout is on practical risk assessment, highlighting applications of toxicogenomics in the risk assessment process across diverse and important areas. Topics include: Applications in mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology The use of toxicogenomics for enhancing mode-of-action and weight-of-evidence approaches The role of toxicogenomics in dose-response analysis, cross-species extrapolations, and animal alternatives The regulatory aspects of toxicogenomics, including chemical classification and prioritization for toxicity testing Strategic approaches for the integration of toxicogenomics in safetyevaluation studies Flap Risk assessment and toxicogenomics -- a practical review The past decade has seen growing interest in the use of toxicogenomics for hazard evaluation and chemical safety assessment. This book addresses the need in the field for a comprehensive, up-to-date review of this emerging technology, providing toxicologists and regulatory scientists with practical considerations to take advantage of toxicogenomics when conducting risk assessment of industrial chemicals, pharmaceuticals, agrochemicals, and consumer products. Written by leading scientists experienced in the application of toxicogenomics data, this book includes a complete introduction to toxicogenomics and the principles of risk assessment, examines the potential of the technology to improve risk assessment practices, and offers insight into promising future trends. The emphasis throughout is on practical risk assessment, highlighting applications of toxicogenomics in the risk assessment process across diverse and important areas. Topics include: Applications in mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology The use of toxicogenomics for enhancing mode-of-action and weight-of-evidence approaches The role of toxicogenomics in dose-response analysis, cross-species extrapolations, and animal alternatives The regulatory aspects of toxicogenomics, including chemical classification and prioritization for toxicity testing Strategic approaches for the integration of toxicogenomics in safetyevaluation studies Author Biography DARRELL R. BOVERHOF, PhD, is a Senior Toxicology Specialist at The Dow Chemical Company where he leads research programs on respiratory allergy and sensitization, nanotoxicology, and toxicogenomics. Dr. Boverhof has authored or coauthored numerous peer-reviewed publications, review articles, and book chapters in the area of toxicogenomics and serves on the editorial board of the journal Toxicological Sciences. B. BHASKAR GOLLAPUDI, PhD, is the Scientific Director of Mammalian Toxicology at The Dow Chemical Companys Global Toxicology & Environmental Research Laboratory. Dr. Gollapudi has authored or co-authored more than 80 scientific publications. He is an Associate Editor of the journal Toxicological Sciences and is currently serving as an adjunct Associate Professor of Toxicology in the Department of Public Health at the University of Michigan. Table of Contents PREFACE ix CONTRIBUTORS xi 1 TOXICOLOGY, "OMICS" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER 1 Darrell R. Boverhof and B. Bhaskar Gollapudi 2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT 13 Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and Lynne T. Haber 3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD 41 Darrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel 4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA 65 Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi 5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS 81 Jiri Aubrecht and Ebru Caba 6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS 99 Mark R. Fielden 7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY 117 Jorge M. Naciff and George P. Daston 8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING 147 M. Ann Mongan and Hisham K. Hamadeh 9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS 177 Cliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith 10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT 207 Daniel L. Villeneuve, Dalma Martinovi´c, and Gerald T. Ankley 11 ANALYSIS OF TRANSCRIPTOMIC DOSE–RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT 237 Russell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen 12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES 251 Alan Dombkowski and J. Craig Rowlands 13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES 267 Anne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans 14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK 293 Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson 15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN 323 Ken-ichi Aisaki and Jun Kanno 16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION 331 Lois D. Lehman-McKeeman and William R. Foster 17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH 349 Sarah N. Campion and Kim Boekelheide INDEX 357 Long Description Risk assessment and toxicogenomics a practical review The past decade has seen growing interest in the use of toxicogenomics for hazard evaluation and chemical safety assessment. This book addresses the need in the field for a comprehensive, up-to-date review of this emerging technology, providing toxicologists and regulatory scientists with practical considerations to take advantage of toxicogenomics when conducting risk assessment of industrial chemicals, pharmaceuticals, agrochemicals, and consumer products. Written by leading scientists experienced in the application of toxicogenomics data, this book includes a complete introduction to toxicogenomics and the principles of risk assessment, examines the potential of the technology to improve risk assessment practices, and offers insight into promising future trends. The emphasis throughout is on practical risk assessment, highlighting applications of toxicogenomics in the risk assessment process across diverse and important areas. Topics include: Applications in mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology The use of toxicogenomics for enhancing mode-of-action and weight-of-evidence approaches The role of toxicogenomics in dose-response analysis, cross-species extrapolations, and animal alternatives The regulatory aspects of toxicogenomics, including chemical classification and prioritization for toxicity testing Strategic approaches for the integration of toxicogenomics in safetyevaluation studies Details ISBN0470449829 ISBN-10 0470449829 ISBN-13 9780470449820 Format Hardcover Author B. Bhaskar Gollapudi Short Title APPLICATIONS OF TOXICOGENOMICS Language English Media Book DEWEY 616.042 Edited by B. Bhaskar Gollapudi Illustrations Illustrations Edition 1st Country of Publication United States Place of Publication New York UK Release Date 2011-07-15 AU Release Date 2011-08-02 NZ Release Date 2011-08-02 Publisher John Wiley & Sons Inc Year 2011 Publication Date 2011-07-15 Imprint John Wiley & Sons Inc Audience Professional & Vocational US Release Date 2011-07-15 Pages 392 We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:132128210;

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