An Introduction to Markov State Models and Their Application to Long Timescal...

Description: An Introduction to Markov State Models and Their Application to Long Timescale Molecular Simulation (Advances in Experimental Medicine and Biology, 797) [Paperback] Bowman, Gregory R.; Pande, Vijay S. and No�, Frank Product Overview The aim of this book volume is to explain the importance of Markov state models to molecular simulation, how they work, and how they can be applied to a range of problems.The Markov state model (MSM) approach aims to address two key challenges of molecular simulation:1) How to reach long timescales using short simulations of detailed molecular models.2) How to systematically gain insight from the resulting sea of data.MSMs do this by providing a compact representation of the vast conformational space available to biomolecules by decomposing it into states sets of rapidly interconverting conformations and the rates of transitioning between states. This kinetic definition allows one to easily vary the temporal and spatial resolution of an MSM from high- resolution models capable of quantitative agreement with (or prediction of) experiment to low-resolution models that facilitate understanding. Additionally, MSMs facilitate the calculation of quantities that are difficult to obtain from more direct MD analyses, such as the ensemble of transition pathways.This book introduces the mathematical foundations of Markov models, how they can be used to analyze simulations and drive efficient simulations, and some of the insights these models have yielded in a variety of applications of molecular simulation. Read more Details Publisher ‏ : ‎ Springer; Softcover reprint of the original 1st ed. 2014 edition (September 18, 2016) Language ‏ : ‎ English Paperback ‏ : ‎ 151 pages ISBN-10 ‏ : ‎ 9402407626 ISBN-13 ‏ : ‎ 24 Item Weight ‏ : ‎ 9.8 ounces Dimensions ‏ : ‎ 7.01 x 0.35 x 10 inches Best Sellers Rank: #9,721,842 in Books (See Top 100 in Books) #133 in Biomathematics #1,660 in Physical Chemistry #2,314 in Bioinformatics (Books) #133 in Biomathematics #1,660 in Physical Chemistry We have been selling used books since 2012, and we've learned that the most important thing is doing good business. Honesty is our policy. Free Shipping We ship worldwide. We have multiple warehouses around the world, so please note the extended handling time on certain listings.

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